Tolterodine tartrate is a white, crystalline powder with a molecular weight of 475. This medicine may cause some people to become dizzy, drowsy, or have blurred vision. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy, not alert, or not able to see well. Absorbent products such as mini-shields that attach to underwear or plastic-backed diapers. These items help you guard against accidents. Most of them are disposable, but you can also buy absorbent cloths that you can wash and reuse. The benefit of the treatment should be re-evaluated after 2 or 3 months.
Tolterodine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. One percent of patients treated with Detrol discontinued treatment due to dry mouth. Taking tolterodine with your heart medicine may affect your heart's rhythm may increase your risk of an irregular heartbeat, which may be life-threatening. This medicine is available only with your doctor's prescription.
Potassium Citrate: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Citrate. Use with caution and at reduced doses. Do you drink alcohol or caffeinated beverages? Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. It's also important to eat high-fiber foods, because may worsen the symptoms of syndrome.
Warfarin: Tolterodine may enhance the anticoagulant effect of Warfarin. Has occurred and required hospitalization and emergency medical treatment. Tolterodine Tartrate Tablets were evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency in four randomized, double-blind, placebo-controlled, 12-week studies. A total of 853 patients received Tolterodine Tartrate Tablets 2 mg twice daily and 685 patients received placebo. The majority of patients were Caucasian 95% and female 78% with a mean age of 60 years range, 19 to 93 years. At study entry, nearly all patients perceived they had urgency and most patients had increased frequency of micturitions and urge incontinence. These characteristics were well balanced across treatment groups for the studies.
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Pharmacokinetic studies revealed that tolterodine is metabolized at a slower rate in poor metabolizers than in extensive metabolizers; this results in significantly higher serum concentrations of tolterodine and in negligible concentrations of 5-HMT. Take this by with or without food as directed by your doctor, usually once a day. Swallow the medication whole with a full glass of liquid. not crush or chew the medication. Doing so can destroy the long action of the drug and may increase side effects. The difference between DETROL and placebo was statistically significant. Oxytrol in pill form by prescription will still be available. Sacral nerve stimulation is a treatment in which mild electrical impulses are sent to the sacral nerves near the lower back. A device -- implanted in the upper buttocks under the skin -- is used to provide electrical pulses that influence bladder function. The procedure to implant the device does involve surgery, but it is minimally invasive, and reversible. Store mirabegron at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep mirabegron out of the reach of children and away from pets. Overdosage with tolterodine tartrate extended-release capsules can potentially result in severe central anticholinergic effects and should be treated accordingly. Some of the side effects that can occur with tolterodine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Kalamazoo, MI; 2001 Apr. It is not known if tolterodine, the active substance of Detrusitol, is excreted in the mother's breast milk.
Oxytrol for Women is in the form of a patch, applied to the skin every four days, Merck says. Medicines like Tolterodine Tartrate Tablets can cause blurred vision, dizziness, and drowsiness. Do not drive, operate machinery, or do other dangerous activities until you know how Tolterodine Tartrate Tablets affect you. Keep Detrusitol out of the sight and reach of children. Discuss specific use of drug and side effects with patient as it relates to treatment. HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? The efficacy endpoints for studies 008, 009, and 010 see were identical to the above endpoints with the exception that the number of incontinence episodes was per 24 hours averaged over 7 days. National Association for Continence: "Overactive Bladder Syndrome. Because these spontaneously reported events are from the worldwide postmarketing experience, the frequency of events and the role of tolterodine in their causation cannot be reliably determined. Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates. Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely particularly therapeutic effects. CYP3A4 inhibitors: Dosage adjustment is recommended in patients receiving CYP3A4 inhibitors; a lower dose of tolterodine is recommended. Ultrasonography. A diagnostic imaging test using sound waves to visualize an internal body structure. Detrol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. If you are breastfeeding. Tolterodine Tartrate Tablets are indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.
Take DETROL LA capsules once a day with liquid. Swallow the whole capsule. Tolterodine Tartrate Tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The child fully recovered. Detrol Tablets 2 mg was treated with a suspension of activated charcoal and was hospitalized overnight with symptoms of dry mouth. The child fully recovered. Tolterodine tartrate extended-release capsules, 2 mg were evaluated in 29 patients in a Phase 2 dose-effect study. Tolterodine tartrate extended-release capsules, 4 mg were evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, 12 week study. A total of 507 patients received tolterodine tartrate extended-release capsules, 4 mg once daily in the morning and 508 received placebo. The majority of patients were Caucasian 95% and female 81% with a mean age of 61 years range, 20 to 93 years. In the study, 642 patients 42% were 65 to 93 years of age. The study included patients known to be responsive to tolterodine immediate release and other anticholinergic medications, however, 47% of patients never received prior pharmacotherapy for overactive bladder. At study entry, 97% of patients had at least 5 urge incontinence episodes per week and 91% of patients had 8 or more micturitions per day. Eat a well-. Foods high in potassium include bananas, oranges, cantaloupe, raisins, dates, prunes, avocados, apricots, beans, broccoli, spinach, potatoes, lentils, chicken, turkey, beef, and yogurt. Consult your doctor or dietician for recommended foods. Based on these findings, other potent CYP3A4 inhibitors may also lead to increases of tolterodine plasma concentrations. CYP2D6 extensive metabolizers had low serum concentrations of tolterodine and high concentrations of the active metabolite 5-HMT, while poor metabolizers had high concentrations of tolterodine and negligible active metabolite concentrations. LA based on AUC of tolterodine and its 5-HMT metabolite.
Most people get enough potassium by eating a well-. GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. The data described below reflect exposure to Detrol 2 mg bid in 986 patients and to placebo in 683 patients exposed for 12 weeks in five Phase 3, controlled clinical studies. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. The adverse reaction information from clinical trials does, however, provide a basis for identifying the adverse events that appear to be related to drug use and approximating rates. The microscopic examination of urine that also involves a number of tests to detect and measure various compounds that pass through the urine. Administer tolterodine tartrate extended-release capsules with caution in patients with gastrointestinal obstructive disorders because of the risk of gastric retention. Dry mouth, constipation, abnormal vision accommodation abnormalities urinary retention, and xerophthalmia are expected side effects of antimuscarinic agents. Bozeman says. "Then walk slowly to the bathroom. Difficulty starting to urinate. What are possible side effects of Tolterodine Tartrate Tablets? The following side effects have been observed in Detrusitol with the following frequencies. Risk of blurred vision, dizziness, or drowsiness. 1 2 3 23 Use caution when engaging in potentially hazardous activities until effects on individual are known.
Taking a road trip? There may be new information. The anticoagulant effect of warfarin may be increased. Monitor anticoagulant activity and adjust the warfarin dose as needed. Take Detrol at the same times each day. Use with caution in patients with myasthenia gravis. Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Both urinary bladder contraction and salivation are mediated via cholinergic muscarinic receptors. Are allergic to DETROL or to any of its ingredients. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious problems. If you miss a dose of Detrol, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. In healthy volunteers, coadministration of tolterodine immediate-release 4 mg 2 mg bid for 7 days and a single dose of warfarin 25 mg on day 4 had no effect on prothrombin time, Factor VII suppression, or on the pharmacokinetics of warfarin.
Dasatinib: May increase the serum concentration of CYP3A4 Substrates. This information should not be used to decide whether or not to take mirabegron or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about mirabegron. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to mirabegron. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using mirabegron. The initial recommended dose of Detrol Tablets is 2 mg twice daily. The dose may be lowered to 1 mg twice daily based on individual response and tolerability. But she says that for women who are able, and lifestyle changes that include drinking less and watching fluid intake are likely to have bigger impacts on the condition. The effect of 200 mg daily dose of ketoconazole on the pharmacokinetics of tolterodine immediate release was studied in 8 healthy volunteers, all of whom were poor metabolizers see for discussion of poor metabolizers.
Continued How is overactive bladder diagnosed? DETROL may cause allergic reactions that may be serious. The frequency of discontinuation due to adverse events was highest during the first 4 weeks of treatment. Similar percentages of patients treated with tolterodine tartrate extended-release capsules or placebo discontinued treatment due to adverse events. In the study, 642 patients 42% were 65 to 93 years of age. Medicines should not be disposed of via wastewater or household waste. The need to drop everything and race to the bathroom can disrupt your life. And if you leak, even if it's only a little bit, it can be embarrassing.
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Detrol, like other antimuscarinic drugs, should be used with caution in patients with decreased gastrointestinal motility. Overdosage with Detrol can potentially result in severe central anticholinergic effects and should be treated accordingly. These measures will help to protect the environment.
Do not drive, operate machinery, or do other dangerous activities until you know how tolterodine tartrate extended-release capsules affect you. The child fully recovered. QT interval was found to correlate with plasma concentration of tolterodine. There appeared to be a greater QTc interval increase in CYP2D6 poor metabolizers than in CYP2D6 extensive metabolizers after tolterodine treatment in this study.
Tolterodine may cause a condition that affects the rhythm QT prolongation. If your symptoms do not improve or if they become worse, check with your doctor. Glaucoma: Use with caution in patients with controlled treated narrow-angle glaucoma. What are the ingredients in Detrol?
Some people with urinary incontinence may get relief by making simple changes to their lives and that's what experts recommend trying first. In patients with renal impairment, serum concentrations of tolterodine tartrate and 5-hydroxymethyl metabolite following administration of conventional tablets are twofold to threefold or higher than in healthy individuals. 1 23 See Renal Impairment under Dosage and Administration. Liver impairment can significantly alter the disposition of tolterodine immediate release.